Includes bibliographical references.
|Series||Immunological reviews -- no.182|
|The Physical Object|
|Number of Pages||227|
In Regulatory T Cells: Methods and Protocols, experts in the field to offer a collection of current techniques to advance the study of regulatory T cells, including the use of the IL-2 receptor alpha chain and other markers, as well as the more recently desirable use of . From the reviews: “This book is to provide a detailed and up-to-date collection of methods and protocols utilised for the analysis of regulatory T cells. this book would be of most use to scientific researchers, in particular PhD students and post-doctoral researchers, working in the field of regulatory T cells within a laboratory setting. Chapter Ten - The Immune Fulcrum: Regulatory T Cells Tip the Balance Between Pro- and Anti-inflammatory Outcomes upon Infection Laura E. Richert-Spuhler, Jennifer M. . A.M. Thornton, in Comprehensive Toxicology, Regulatory T cells (Tregs) are a subset of CD4+ T cells that express the transcription factor Foxp3 and potently suppress many immune responses. As the field of Tregs has only begun to unfold in the last decade, this chapter will provide a comprehensive background and will discuss the current state of the field of Tregs.
Considerable regulatory function has been attributed to the CD4+CD25+ T-cell subset. These cells act by suppressing adaptive and possibly innate immune responses thereby maintaining or restoring the balance between immunity and tolerance. The suppressive effects of CD4+CD25+ regulatory T-cells are cell-contact dependent. Key Terms. autoimmunity: The condition where one’s immune system attacks one’s own tissues, i.e., an autoimmune disorder.; Regulatory T cells are a component of the immune system that suppress immune responses of other cells. This is an important “self-check” built into the immune system to prevent excessive reactions and chronic inflammation. Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Pages: Chapters: T cell, T helper cell, CCR5, CD4+ T cells and antitumor immunity, T cells, Regulatory T cell, CTLA-4, T cell receptor, Cytotoxic T cell, T helper 17 cell, Memory T cell, Natural Killer T cell, Artificial T cell receptor, Follicular B Helper T. In addition, simvastatin attenuated CD4 T-cell apoptosis induced by sepsis and promotes proliferation of these cells and the production of cytokines, and contrary to the effect of the treatment in healthy mice, simvastatin reduces the expansion of regulatory T cells in septic littermates, which correlated with a reduced bacteremia in septic Cited by:
Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis. Tregs suppress the function of other T cells to limit the immune response. Alterations in the number and function of Tregs has been implicated in several autoim-mune diseases including multiple sclerosis, active rheumatoid. Purchase Regulatory T-Cells, Volume - 1st Edition. Print Book & E-Book. ISBN , The concept of immunosuppression mediated by T cells is a remarkable example in the history of science. The use of CD4 and CD25 as defining surface markers and the renaming of T suppressor cells into "regulatory T cells" (T REGS) by one of the pioneers in the field, Shimon Sakaguchi, was a key step toward the rediscovery and rehabilitation of these fundamental Author: Luciana Berod, Katharina Lahl, Katharina Lahl, Matthias Lochner, Christian T. Mayer, Tim Sparwasser. Machine generated contents note: ch. 1 T Helper 17 Cells Interplay with CD4+CD25highFoxp3+ Regulatory T cells in Regulating Autoimmune Inflammation / Xiao-Feng Yang --ch. 2 Human CD8 Tregs as Contender in Chronic Persisting Infections / Tom H. M. Ottenhoff --ch. 3 Role of Regulatory t Cells in the Treatment of Multiple Sclerosis / W. van Eden.